Novel library synthesis of 3,4-disubstituted pyridin-2(1H)-ones via cleavage of pyridine-2-oxy-7-azabenzotriazole ethers under ionic hydrogenation conditions at room temperature

In our hands, efficient access to the Sexual Wellness 4-amino-3-carboxamide disubstituted pyridine-2(1H)-one kinase hinge-binder motif proved to be more challenging than anticipated requiring a significant investment in route scouting and optimization.This full paper focuses on the synthesis issues that we encountered during our route exploration a

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A COVID-19 Test Triage Tool, Predicting Negative Results and Reducing the Testing Burden on Healthcare Systems During a Pandemic

Background: Detecting and isolating cases of COVID-19 are amongst the key elements listed by the WHO to reduce transmission.This approach has been reported to reduce those symptomatic with COVID-19 in the population by over 90%.Testing is part of a strategy that will save lives.Testing Drinkware Sets everyone maybe ideal, but it is not practical.A

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